reviewTop 10% cited
Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles
Free Radical Biology and Medicine · 2004 · Vol. 36(10) · pp. 1208–1213
Ken Itoh(University of Tsukuba)Kit I. Tong(University of Tsukuba)Masayuki Yamamoto✉(University of Tsukuba)
Genomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsKEAP1Transcription factorPsychological repressionCell biologyMechanism (biology)ElectrophileChemistryLeucine zipperBiochemistryBiology
MeSH terms
Kelch-Like ECH-Associated Protein 1AnimalsAntioxidantsCytoskeletal ProteinsDNA-Binding ProteinsGene Expression RegulationHumansSignal TransductionTranscriptional ActivationTrans-ActivatorsOxidative StressResponse ElementsAdaptor Proteins, Signal TransducingNF-E2-Related Factor 2
Funding
- Naito Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Core Research for Evolutional Science and Technology
- Exploratory Research for Advanced Technology
Citations
854
FWCI
7.81
field-weighted impact
References
65
Percentile
98%
vs. same field & year
Citations per year
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References
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Biochemical and Biophysical Research Communications · 1997 · 3,915 citations
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival
Molecular and Cellular Biology · 2003 · 1,204 citations
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Genes & Development · 1999 · 3,543 citations
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
Molecular and Cellular Biology · 2003 · 1,425 citations
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