articleTop 1% cited
Molecular determinants of resistance to antiandrogen therapy
Nature Medicine · 2003 · Vol. 10(1) · pp. 33–39
Charlie D. Chen✉(University of California, Los Angeles)Derek S. Welsbie(University of California, Los Angeles)Chris Tran(University of California, Los Angeles)Sung Hee Baek(Howard Hughes Medical Institute)Randy Chen(University of California, Los Angeles)Robert L. Vessella(University of Washington)Michael G. Rosenfeld(University of California, Los Angeles)Charles L. Sawyers(Howard Hughes Medical Institute)
Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsHormonal and reproductive studiesAntiandrogensAndrogen receptorAntiandrogenProstate cancerEndocrinologyAndrogenInternal medicineAgonistFlutamideReceptor
MeSH terms
Androgen AntagonistsBase SequenceHumansMaleProstatic NeoplasmsReceptors, AndrogenDNA PrimersDisease ProgressionAntineoplastic Agents, HormonalDrug Resistance, Neoplasm
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References
The development of androgen-independent prostate cancer
Nature reviews. Cancer · 2001 · 2,308 citations
A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens
Biochemical and Biophysical Research Communications · 1990 · 941 citations
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