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Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia

Leukemia · 2004 · Vol. 18(4) · pp. 676–684
Chihaya ImaiKeichiro MiharaMartin AndreánskyI. NicholsonC‐H PuiTerrence L. GeigerDario Campana
CAR-T cell therapy researchImmune Cell Function and InteractionImmunotherapy and Immune ResponsesCD19ReceptorBiologyChimeric antigen receptorCancer researchLeukemiaImmunologyCell biologyMolecular biologyT cell

MeSH terms

Burkitt LymphomaCytotoxicity Tests, ImmunologicHumansImmunoglobulin Variable RegionImmunotherapyRecombinant Fusion ProteinsT-LymphocytesTransduction, GeneticAntigens, CDCD8 AntigensCD3 ComplexProtein Structure, TertiaryReceptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorImmunoconjugates

Funding

  • American Cancer Society
  • American Lebanese Syrian Associated Charities
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