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Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

Acta Neuropathologica · 2010 · Vol. 120(6) · pp. 707–718

Christian Hartmann✉(German Cancer Research Center)Bettina Hentschel(Leipzig University)Wolfgang Wick(German Cancer Research Center)David Capper(Heidelberg University)Jörg Felsberg(Heinrich Heine University Düsseldorf)Matthias Simon(University of Bonn)Manfred Westphal(Universität Hamburg)Gabriele Schackert(TU Dresden)Richard Meyermann(University of Tübingen)Torsten Pietsch(University of Bonn)Guido Reifenberger(Heinrich Heine University Düsseldorf)Michael Weller(University Hospital of Zurich)Markus Loeffler(Leipzig University)Andreas von Deimling(Heidelberg University)

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Glioma Diagnosis and Treatment MicroRNA in disease regulation Ferroptosis and cancer prognosisAnaplastic astrocytomaIDH1Isocitrate dehydrogenaseAstrocytomaMedicineGliomaOncologyPathologyInternal medicineGrading (engineering)

MeSH terms

AdolescentAdultAge FactorsAgedAged, 80 and overAstrocytomaBrain NeoplasmsFemaleGlioblastomaGliomaHumansIsocitrate DehydrogenaseMaleMiddle AgedMutation

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Frequent ATRX , CIC , FUBP1 and IDH1 mutations refine the classification of malignant gliomas