article Open AccessTop 1% cited

Fusobacterium nucleatumin colorectal carcinoma tissue and patient prognosis

Gut · 2015 · Vol. 65(12) · pp. 1973–1980

Kosuke Mima(Harvard University)Reiko Nishihara(Harvard University)Zhi Rong Qian(Dana-Farber Cancer Institute)Yin Cao(Harvard University)Yasutaka Sukawa(Dana-Farber Cancer Institute)Jonathan A. Nowak(Harvard University)Juhong Yang(Harvard University)Ruoxu Dou(Dana-Farber Cancer Institute)Yohei Masugi(Harvard University)Mingyang Song(Harvard University)Aleksandar D. Kostic(Massachusetts General Hospital)Marios Giannakis(Massachusetts Institute of Technology)Susan Bullman(Dana-Farber Cancer Institute)Danny A. Milner(Harvard University)Hideo Baba(Kumamoto University)Edward L. Giovannucci(Brigham and Women's Hospital)Levi A. Garraway(Harvard University)Gordon J. Freeman(Brigham and Women's Hospital)Glenn Dranoff(Harvard University)Wendy S. Garrett(Massachusetts Institute of Technology)Curtis Huttenhower(Massachusetts Institute of Technology)Matthew Meyerson(Massachusetts Institute of Technology)Jeffrey A. Meyerhardt(Dana-Farber Cancer Institute)Andrew T. Chan(Brigham and Women's Hospital)Charles S. Fuchs(Brigham and Women's Hospital)Shuji Ogino✉(Brigham and Women's Hospital)

View via DOI Publisher page

Abstract

The amount of F. nucleatum DNA in colorectal cancer tissue is associated with shorter survival, and may potentially serve as a prognostic biomarker. Our data may have implications in developing cancer prevention and treatment strategies through targeting GI microflora by diet, probiotics and antibiotics.

Colorectal Cancer Screening and Detection Diverticular Disease and Complications Gut microbiota and healthFusobacterium nucleatumColorectal cancerMicrosatellite instabilityKRASMedicineOncologyInternal medicineProportional hazards modelDNA methylationHazard ratio

MeSH terms

AgedCarcinomaFemaleFollow-Up StudiesHumansMaleMiddle AgedMutationNeoplasm StagingPhenotypePrognosisProspective StudiesResearch DesignBiomarkers, TumorColorectal Neoplasms

Citations

1,035

FWCI

21.55

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

The Intestinal Microbiota and Colorectal Cancer