reviewTop 1% cited
Ischaemia-reperfusion injury
British journal of surgery · 1994 · Vol. 81(5) · pp. 637–647
P. A. Grace✉(Hammersmith Hospital)
Abstract
Ischaemia-reperfusion injury is a complex phenomenon often encountered in surgical practice. The consequences of such injury are local and remote tissue destruction, and sometimes death. Several different processes have been implicated. This review discusses the pathology of such injury, the mechanisms of free radical production, and the role of neutrophils and endothelial factors in ischaemia-reperfusion. Finally, several mechanisms that limit ischaemia-reperfusion injury are discussed and a number of novel therapies presented.
Cardiac Ischemia and ReperfusionCardiac Arrest and ResuscitationNitric Oxide and Endothelin EffectsMedicineIschemiaReperfusion injuryMyocardial ischaemiaIntensive care medicineInternal medicine
MeSH terms
AnimalsEndothelium, VascularFree RadicalsHumansNeutrophilsReperfusion InjuryArachidonic AcidReactive Oxygen Species
Citations
722
FWCI
12.88
field-weighted impact
References
199
Percentile
99%
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Citations per year
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References
Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
American Journal of Physiology-Heart and Circulatory Physiology · 1986 · 1,185 citations
Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide
Archives of Biochemistry and Biophysics · 1991 · 2,199 citations
Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil
British journal of surgery · 1991 · 513 citations
Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.
Stroke · 1989 · 1,110 citations
Multiple Organ Failure Pathophysiology and Potential Future Therapy
Annals of Surgery · 1992 · 1,390 citations
Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
Archives of Biochemistry and Biophysics · 1986 · 2,043 citations
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Nature · 1987 · 10,729 citations
Endothelin is a potent mitogen for rat vascular smooth muscle cells
Atherosclerosis · 1989 · 505 citations
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