articleTop 10% cited

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

Neurobiology of Aging · 2003 · Vol. 24(8) · pp. 1063–1070

Salvatore Oddo✉(University of California, Irvine)

Alzheimer's disease research and treatments Prion Diseases and Protein Misfolding Dementia and Cognitive Impairment ResearchNeuropathologyNeurofibrillary tangleTanglePresenilinNeuroscienceTransgeneTau proteinGenetically modified mouseTauopathyHippocampus

MeSH terms

Alzheimer DiseaseAnimalsBrainDisease Models, AnimalHumansMembrane ProteinsMice, TransgenicMutationAmyloid beta-Protein PrecursorNeurofibrillary Tanglestau ProteinsDisease ProgressionMicePresenilin-1Plaque, Amyloid

Funding

National Institutes of Health
University of California, Irvine

Citations

997

FWCI

8.86

field-weighted impact

References

Percentile

98%

vs. same field & year

Citations per year

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References

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

Neuron · 2003 · 4,102 citations

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

Science · 2002 · 13,715 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Nature Medicine · 1996 · 2,586 citations

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Physiological Reviews · 2001 · 6,050 citations

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

Neurobiology of Aging · 2003 · 997 citations

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