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Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

FEBS Letters · 1988 · Vol. 238(2) · pp. 249–252

Issei Komuro✉(The University of Tokyo)Hiroki Kurihara(The University of Tokyo)Takao Sugiyama(The University of Tokyo)Fumimaro Takaku(The University of Tokyo)Yoshio Yazaki(The University of Tokyo)

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Abstract

Recently, a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells. We examined its effect on rat vascular smooth muscle cells (VSMCs). EDT induced the elevation of intracellular calcium, which was dependent on extracellular calcium and inhibited by a calcium-channel antagonist in a competitive manner. EDT caused a rapid and transient increase in the c-fos and c-myc mRNA levels and stimulated the DNA synthesis of VSMCs in a dose-dependent manner. This effect of EDT on the proliferation of VSMCs might be related to the development of atherosclerosis.

Nitric Oxide and Endothelin Effects Renin-Angiotensin System Studies Receptor Mechanisms and SignalingVascular smooth muscleEndothelin 1ChemistrySmooth muscleCell biologyc-FosEndothelin receptorCell growthEndocrinologyMolecular biology

MeSH terms

AnimalsCalciumCell DivisionDNAEndothelium, VascularGene Expression RegulationKineticsMuscle, Smooth, VascularPeptidesProto-Oncogene ProteinsRNA, MessengerEndothelinsProto-Oncogene Proteins c-mycProto-Oncogene Proteins c-fosRats

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