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Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis

The American Journal of Gastroenterology · 2003 · Vol. 98(11) · pp. 2485–2490

Stephen A. Harrison✉(The University of Texas Health Science Center at San Antonio)Sigurd Torgerson(The University of Texas Health Science Center at San Antonio)Paul H. Hayashi(The University of Texas Health Science Center at San Antonio)John A. Ward(The University of Texas Health Science Center at San Antonio)Steven Schenker(Wilford Hall Medical Center)

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Abstract

Forty-five patients completed 6 months of therapy without significant side effects. Vitamin treatment resulted in a statistically significant improvement in fibrosis score (p=0.002). No changes were noted in inflammation with treatment. Vitamin E and vitamin C, in the doses used in this study, were well tolerated and were effective in improving fibrosis scores in NASH patients. No improvement in necroinflammatory activity or ALT was seen with this combination of drug therapy. A larger, multicenter, longer-term trial with vitamin E and vitamin C seems to be warranted.

Liver Disease Diagnosis and Treatment Liver Disease and Transplantation Alcohol Consumption and Health EffectsMedicineGastroenterologyInternal medicineCirrhosisPlaceboFibrosisSteatohepatitisVitamin ENonalcoholic fatty liver diseaseRandomized controlled trial

MeSH terms

Analysis of VarianceAntioxidantsAscorbic AcidBiopsy, NeedleDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationFatty LiverFemaleFollow-Up StudiesHumansLiver CirrhosisMaleMiddle Aged

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