review Open AccessTop 10% cited
E‐Cadherin/<i>β</i>‐Catenin Complex and the Epithelial Barrier
BioMed Research International · 2011 · Vol. 2011(1) · pp. 567305–567305
Xinrui Tian✉(University of Sydney)Zhuo-la Liu(Shanxi Medical University)Bo Niu(Capital Institute of Pediatrics)Jianlin Zhang(Shanxi Medical University)Thian Kui Tan(University of Sydney)So Ra Lee(University of Sydney)Ye Zhao(University of Sydney)David C.H. Harris(University of Sydney)Guoping Zheng(University of Sydney)
Abstract
E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.
Wnt/β-catenin signaling in development and cancerCancer-related gene regulationKruppel-like factors researchCadherinCateninVE-cadherinChemistryCell biologyBiologySignal transductionBiochemistryWnt signaling pathway
MeSH terms
Epithelial CellsEpitheliumFibrosisHumansNeoplasmsCadherinsbeta CateninEpithelial-Mesenchymal TransitionWnt Signaling Pathway
Citations
422
FWCI
7.32
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References
76
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98%
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References
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