article Open AccessTop 1% cited
Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease
Nature Structural & Molecular Biology · 2015 · Vol. 22(6) · pp. 499–505
Yiling Xiao(University of Illinois Chicago)Buyong Ma(Leidos (United States))Dan McElheny(University of Illinois Chicago)Sudhakar Parthasarathy(University of Illinois Chicago)Fei Long(University of Illinois Chicago)Minako Hoshi(Kyoto University)Ruth Nussinov(Leidos (United States))Yoshitaka Ishii✉(University of Illinois Chicago)
Alzheimer's disease research and treatmentsSupramolecular Self-Assembly in MaterialsAdvanced NMR Techniques and ApplicationsFibrilSalt bridgeChemistryAmyloid (mycology)Amyloid fibrilBiophysicsMonomerAmyloid βCrystallographyDisease
MeSH terms
Alzheimer DiseaseHumansModels, MolecularMagnetic Resonance SpectroscopyPeptide FragmentsProtein BindingProtein ConformationAmyloid beta-PeptidesProtein FoldingProtein Multimerization
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References
Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils
Nature Structural & Molecular Biology · 2010 · 1,085 citations
Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease
Nature Chemistry · 2009 · 908 citations
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
Neuron · 1994 · 1,756 citations
Effect of Environmental Factors on the Kinetics of Insulin Fibril Formation: Elucidation of the Molecular Mechanism
Biochemistry · 2001 · 1,188 citations
Experimental Constraints on Quaternary Structure in Alzheimer's β-Amyloid Fibrils
Biochemistry · 2005 · 1,046 citations
Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid
Nature Structural & Molecular Biology · 2007 · 542 citations
Alzheimer's Disease: Genes, Proteins, and Therapy
Physiological Reviews · 2001 · 6,050 citations
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