article Open AccessTop 1% cited
Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
Nature Structural & Molecular Biology · 2016 · Vol. 23(5) · pp. 409–415
Marcus D. Tuttle(University of Illinois Urbana-Champaign)Gemma Comellas(University of Illinois Urbana-Champaign)Andrew J. Nieuwkoop(University of Illinois Urbana-Champaign)Dustin J. Covell(University of Pennsylvania)Dominik Berthold(University of Illinois Urbana-Champaign)Kathryn D. Kloepper(University of Illinois Urbana-Champaign)Joseph M. Courtney(University of Illinois Urbana-Champaign)Jae Kwang Kim(University of Illinois Urbana-Champaign)Alexander M. Barclay(University of Illinois Urbana-Champaign)Amy Kendall(Vanderbilt University)William Wan(Vanderbilt University)Gerald Stubbs(Vanderbilt University)Charles D. Schwieters(National Institutes of Health)Virginia M.‐Y. Lee(Institute on Aging)Julia M. George(Queen Mary University of London)Chad M. Rienstra✉(University of Illinois Urbana-Champaign)
Parkinson's Disease Mechanisms and TreatmentsAdvanced NMR Techniques and ApplicationsAdvanced Neuroimaging Techniques and ApplicationsFibrilChemistrySolid-state nuclear magnetic resonanceCrystallographySalt bridgeProtein foldingAmyloid (mycology)Alpha-synucleinBiophysicsAmyloid fibril
MeSH terms
Protein DomainsAmino Acid SequenceAmyloidAnimalsCells, CulturedHumansHydrogen BondingNeuronsParkinson DiseaseLewy BodiesProtein Structure, SecondaryProtein FoldingNuclear Magnetic Resonance, BiomolecularProtein Structure, QuaternaryMice
Funding
- National Science Foundation
- U.S. Department of Energy
- National Institutes of Health
- University of Illinois at Urbana-Champaign
- Division of Materials Research
- Center for Information Technology
- National Center for Research Resources
- Basic Energy Sciences
- Biological and Environmental Research
- Brookhaven National Laboratory
Citations
982
FWCI
80.33
field-weighted impact
References
74
Percentile
100%
vs. same field & year
Citations per year
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References
Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease
Nature Structural & Molecular Biology · 2015 · 823 citations
The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia
Annals of Neurology · 2003 · 2,726 citations
– dipolar-assisted rotational resonance in magic-angle spinning NMR
Chemical Physics Letters · 2001 · 1,046 citations
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Nature Genetics · 1998 · 3,865 citations
Experimental Constraints on Quaternary Structure in Alzheimer's β-Amyloid Fibrils
Biochemistry · 2005 · 1,046 citations
Alpha‐synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
Movement Disorders · 2013 · 654 citations
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Science · 1997 · 8,181 citations
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