review Open AccessTop 1% cited
MicroRNAs in apoptosis, autophagy and necroptosis
Oncotarget · 2015 · Vol. 6(11) · pp. 8474–8490
Zhenyi Su✉(Southeast University)Zuozhang Yang(Kunming General Hospital of Chengdu Military Command)Yongqing Xu(Kunming General Hospital of Chengdu Military Command)Yongbin Chen(Chinese Academy of Sciences)Qiang Yu(Chinese Academy of Sciences)
Abstract
MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for cleavage or translational repression. Numerous miRNAs regulate programmed cell death including apoptosis, autophagy and necroptosis. We summarize how miRNAs regulate apoptotic, autophagic and necroptotic pathways and cancer progression. We also discuss how miRNAs link different types of cell death.
MicroRNA in disease regulationAutophagy in Disease and TherapyRNA Interference and Gene DeliveryNecroptosisAutophagymicroRNAApoptosisMedicineProgrammed cell deathCancer researchCell biologyBiologyGene
MeSH terms
AnimalsAutophagyHumansNecrosisNeoplasm ProteinsNeoplasmsPhagosomesRNA, MessengerRNA, NeoplasmSignal TransductionGene Expression Regulation, NeoplasticApoptosisDisease ProgressionRNA StabilityMicroRNAs
Funding
- National Natural Science Foundation of China
- Kunming Medical University
- Natural Science Foundation of Yunnan Province
- Yunnan Provincial Science and Technology Department
Citations
341
FWCI
16.05
field-weighted impact
References
150
Percentile
100%
vs. same field & year
Citations per year
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