articleTop 1% cited

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

Molecular Pharmacology · 1996 · Vol. 49(2) · pp. 311–318

Erin G. Schuetz✉(St. Jude Children's Research Hospital)W T Beck(St. Jude Children's Research Hospital)John D. Schuetz(St. Jude Children's Research Hospital)

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Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Chemical Reactions and IsotopesCYP3A4CYP3AP-glycoproteinPregnane X receptorEffluxCytochrome P450GlycoproteinPharmacologyBiologyChemistry

MeSH terms

AdenocarcinomaBase SequenceCell LineClotrimazoleColonic NeoplasmsCytochrome P-450 Enzyme SystemDexamethasoneDoxorubicinMultigene FamilyHumansMixed Function OxygenasesMidazolamMolecular Sequence DataPhenobarbitalPhenytoin

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497

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27.69

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Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression