articleTop 1% cited
Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs
Pharmaceutical Research · 1999 · Vol. 16(10) · pp. 1514–1519
J. Kelder✉(SNV Netherlands Development Organisation)Peter D. J. GrootenhuisDenis M. BayadaL. P. C. DelbressineJan‐Peter Ploemen
Molecular spectroscopy and chiralityPharmacological Effects of Natural CompoundsCancer therapeutics and mechanismsPolar surface areaPenetration (warfare)TranscellularPolarDrugChemistryPharmacologyMoleculeMedicinePhysics
MeSH terms
AnimalsBlood-Brain BarrierBrainCentral Nervous System AgentsChemistry, PhysicalChromatography, High Pressure LiquidPharmaceutical PreparationsIntestinal AbsorptionMaleMolecular ConformationPharmacokineticsStructure-Activity RelationshipSurface PropertiesRats, WistarRats
Citations
792
FWCI
9.57
field-weighted impact
References
11
Percentile
99%
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Citations per year
Cited by
Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties
Journal of Medicinal Chemistry · 2000 · 2,969 citations
Prediction of Drug Absorption Using Multivariate Statistics
Journal of Medicinal Chemistry · 2000 · 1,889 citations
References
Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans
Pharmaceutical Research · 1997 · 746 citations
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Advanced Drug Delivery Reviews · 2001 · 17,620 citations
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
Advanced Drug Delivery Reviews · 1997 · 11,043 citations
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