Formulation and evalution of hydrogel base transdermal patches of Flurouracil

Abstract

To solve problems with drug administration, especially oral routes, transdermal drug delivery systems were created. Transdermal medication delivery is a technique that allows drugs to be administered either locally or systemically via the skin's surface. Transdermal patches have significantly benefited the pharmaceutical industry and medical practice by improving the way patients get both new and established medications. Various combinations of hydrogel-based transdermal patches are developed and evaluated using the solvent evaporation method. All formulations' pre-formulation results were approved. The spectral bands are examined using FTIR to determine the chemical interactions between the excipient and the API. The formulations' physicochemical characteristics, including their strength, swellability, surface pH, physical appearance, weight uniformity, folding durability, and % moisture uptake, were evaluated. Conclusion: The best formulation was chosen after in-vitro drug penetration tests were performed on the created patches.