Evaluation of the anti-fibroid activity of a herbal powder on monosodium glutamate-induced uterine fibroid in Wister rats

Abstract

Introduction: The threat posed by uterine fibroid on women is on the rise especially in African and African-American women. This study therefore aimed at evaluating the antifibroid effect of a Herbal powder in wistar rats. Methods: Herbal product was purchase from kubys global concept as off label product. Phytochemical screening was conducted on the power using standard methods. The powder was assessed for acute toxicity in rats. Monosodium glutamate was administered to rats for 30 days to induce uterine fibroid and then treated with Herbal powder at 400mg/kg, 800mg/kg and 1200mg/kg for thirty days. Danazol was used as standard drug at 200mg/kg. The weight ratio of the uterus to the weight of the rats. The estradiol, albumin, liver enzymes, kidney and total protein were assessed using standard kits after the rats were sacrificed. Results: Phytochemical screening revealed the presence of carbohydrate triterpenoids, tannins, anthraquinone glycosides, and alkaloids. Acute toxicity showed Median Lethal Dose (LD50) of 5000mg/kg. The weight ratio of the uterus decreased at 400mg/kg. Conclusion: The Herbal powder is safe at 5000mg/kg and also effective at 400mg/kg. Biochemical analysis shows reduced level of estradiol and albumin as wells total protein. The study therefore supports its use in treating uterine fibroid.