Vasorelaxant effects of genistein, a soybean-derived isoflavonoid, in the isolated coronary arteries of goat

Abstract

Cardiovascular diseases remain a major global health concern, emphasizing the need for new therapeutic approaches. Genistein, a soy-derived isoflavonoid, is known for its vasodilatory properties and potential cardiovascular benefits. This study examines the vasorelaxant effects of genistein in isolated goat coronary arteries. Hearts were collected from a local slaughter house, and circumflex coronary artery rings were prepared and mounted in an organ bath containing Modified Krebs-Henseleit Solution. The artery rings were pre-contracted with 30 mM KCl and then exposed to increasing concentrations of genistein (10⁻8 to 10⁻4.5 M), with vascular responses continuously recorded. Results showed a concentration-dependent relaxation, with significant vasorelaxation starting at 10⁻8 M and reaching a maximum of 111.44±3.95% at 10⁻4.5 M. The pD₂ value of 5.29±0.05 indicates genistein’s potency in inducing vasorelaxation. These findings suggest that genistein may play a significant role in vascular modulation and improving vascular function. Further research is needed to explore its underlying mechanisms and potential applications in cardiovascular health.