articleTop 10% cited
The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
Journal of Pharmacology and Experimental Therapeutics · 1997 · Vol. 283(1) · pp. 46–58
R. Scott Obach✉James G. BaxterTheodore E. ListonB. Michael SilberBarry JonesFiona MacintyreDavid J. RancePhilip Wastall
Pharmacogenetics and Drug MetabolismMetabolomics and Mass Spectrometry StudiesComputational Drug Discovery MethodsPharmacokineticsIn vitroPharmacologyComputational biologyChemistryMedicineBiologyBiochemistry
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577
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References
A physiological approach to hepatic drug clearance
Clinical Pharmacology & Therapeutics · 1975 · 1,877 citations
Physiological Parameters in Laboratory Animals and Humans
Pharmaceutical Research · 1993 · 2,894 citations
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
Biochemical Pharmacology · 1994 · 910 citations
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*
Clinical Pharmacology & Therapeutics · 1996 · 617 citations
Pharmaceutical innovation by the seven UK‐owned pharmaceutical companies (1964‐1985).
British Journal of Clinical Pharmacology · 1988 · 473 citations
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