Evaluation of serum biochemical and anti-cancerous activity of Neolamarckia cadamba against DMBA induced in Wistar rats

Abstract

Neolamarckia cadamba is a medicinal plant reported for various medicinal properties. Anticancer activity of methanolic extract of stem bark of Neolamarckia cadamba on DMBA-induced diabetes and serum biochemical studies were conducted in Wistar rats. Group T1 is designated as the standard control, Group T2 was positive control, i.e. orally administered with DMBA at a dose rate of 20 mg/kg body weight three times a week for five weeks, Group T3 was treated with the standard reference drug Tamoxifen at a dose rate of 3.3 mg/kg body weight and Groups T4 and T5 were treated with methanolic bark extract of Neolamarckia cadamba at a dose rate of 200 and 400 mg/kg body weight, respectively. The observation obtained from ultrasonography examination of rats after the completion of treatment revealed that all the treatment groups (T3, T4, T5) showed that there was regression of the mammary tumour. On the 30th day, Tamoxifen @ 3.3 mg/kg decreases (p