Clinico-biochemical and chemotherapeutic evaluation in bubaline trypanosomosis

Abstract

The present study was undertaken on buffaloes of the Mumbai region suffering from pyrexia, inappetence and dullness. The blood smears of these buffaloes stained with Fields stain were examined to confirm the presence of Trypanosoma evansi. The affected animals were divided into two groups (Group I and Group II), each group consisting of 11 buffaloes. Group I animals were treated with a single dose of diminazene aceturate @ 7.4 mg/kg b. wt. and group II with quinapyramine sulphate & chloride @ 7mg/kg b. wt. along with a common supportive therapy including fluids, B. complex and liver tonics, respectively. The serum biochemical profile of infected buffaloes revealed that the levels of blood GLU, TP and ALB significantly declined and levels of AST, ALT, ALP, BUN and TBIL were markedly increased. The altered values were restored to the normal range on day 15 post-treatment in both groups. The efficacy of quinapyramine sulphate & chloride, and diminazene aceturate was found to be 100 and 89.72 per cent in group II and group I animals, respectively. Group II animals treated with quinapyramine sulphate & chloride showed faster clinical recovery with early clearance of parasitaemia and marked improvement in biochemical indices than group I animals with diminazene aceturate.