Comparative study between some fixed and essential oils on toxicity induced by gentamicin in male albino rats

Abstract

The present study was conducted to assess the effect of fixed mix oils (radish and parley) and essential mix oils (clove and peppermint) administration on gentamicin -induced inflammation, oxidative stress toxicity and kidney injury in male rats. In the present work seventy male albino rats were arranged into seven equal groups. Control (G1); carrier group (G2); gentamicin group (G3); fixed mix oils group (G4); essential mix oils group (G5); co-treated group included rats that received fixed mix oils and injected at the same time by gentamicin (G6); co-treated group included rats that received essential mix oils and injected at the same time by gentamicin (G7). The administration of gentamicin revealed a significant increase in levels of serum kidney function (urea, creatinine and uric acid), liver function (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase), lipid profile (cholesterol and triglyceride), tumor necrosis factor-alpha, malondialdehyde, parathyroid hormone and white blood cells count as compared to control group. In contrast; a significant decrease in albumin, superoxide dismutase, catalase, calcium and phosphorus ions levels, Osteocalcin, triiodothyronine, red blood cells count and hemoglobin were observed in gentamicine group as compared to control. The oral supplementation of fixed mix oils and essential mix oils has significantly attenuated the severity of gentamicin-induced oxidative stress. Both two mixtures of oils have potential antioxidant synergistic effect to ameliorate nephrotoxicity and changes in hematological, bone homeostasis and liver function induced by gentamicin. It could be concluded that fixed mix oils (radish and parsley) as well as essential mix oils (clove and peppermint) considered as a natural substance and has a promising protective effect against toxicity induced by gentamicin. Both of these mixtures of oils have nearly the same antioxidant activities. So it is easier to use the fixed oil mixture of low coast than essential oil of high coasted.