Phytochemical screening, analgesic, anti-hyperglycemic and hepatoprotective potentials of Codariocalyx motorius (Houtt.) Leaves Extract

Abstract

This study was performed on Codariocalyx motorius (Houtt.) leaves commonly known as telegraph plant, is a member of the Fabaceae family, to investigate the phytochemical and various pharmacological activities. Qualitative and quantitative phytochemical screenings confirmed the existence of a variety of phytochemical groups. Total phenolic, flavonoid and tannin contents were 81.24 mg gallic acid equivalence/g, 190.90 mg quercetin equivalence/g and 77.29 mg gallic acid equivalence/g, respectively in the extract. In acetic acid-induced writhing model, the extract inhibited the writhing reflex by 49.4% at a dose of 500 mg/kg body weight. In Oral glucose tolerance test, the extract reduced blood glucose levels in a dose-dependent manner in hyperglycemic mice. The extract treated mice also showed the reduction of bilirubin, SGPT, SGOT, and ALP levels in a dose-dependent manner in paracetamol induced hepatoprotective test, when the doses were given of 250 and 500 mg/kg. The outcomes of these experiments support the applications of this plant in conventional medicine.