Catechin enhances the antitumour activity of Bleomycin in DMBA-induced mammary carcinoma in rats

Abstract

In present study, the therapeutic potential and synergistic effects of a combination of bleomycin and catechin were evaluated in mammary tumor animal models. Forty female Wistar rats were divided into five groups: normal control, disease control, bleomycin treatment, catechin treatment, and a combination of catechin and bleomycin treatment. Mammary tumors were induced using 7,12-dimethylbenz[a]-anthracene (DMBA) administered via intragastric tube. After 45-60 days, animals in tumor-induced groups exhibited clinical signs of tumorous tissue development, leading to decreased body weights on days 60 and 90 compared to the normal and treatment groups. However, significant improvements in serum estrogen levels and histopathological lesions were observed in the group receiving a combination of catechin and bleomycin, indicating a potential therapeutic synergy in treating mammary tumors. These findings suggest the promising efficacy of the combined treatment approach in addressing mammary tumors in experimental models.