Role of ameliorating agents in mitigating pesticide-induced toxicity in albino rats as a mammalian model: A review

Abstract

Pesticides like organophosphates, carbamates, pyrethroids, and neonicotinoids have a significant impact on the liver, kidney, brain, lungs causing organ degeneration, hormonal disturbances, reproductive abnormalities, inflammation, oxidative stress, and even potential organ dysfunction in albino rats which are commonly used as model organisms due to their physiological similarities to humans. The ameliorating agents like vitamin C, vitamin E, curcumin, green tea, ginger and garlic have the potential to counteract damage caused by pesticides by neutralizing reactive oxygen species and mitigating oxidative stress in rats. Overall, this comprehensive review discusses the importance of studying the role of ameliorating agents in alleviating pesticide-induced toxicity in albino rats, thus exploring the potential of these agents for mitigating the harmful effects of pesticides on human health and the environment.