Triglyceride glucose index as a novel biomarker to identify severity of acute pancreatitis

Abstract

Background: Reduced morbidity and mortality may be achieved with prompt detection of severe acute pancreatitis (AP). The purpose of this research is to demonstrate a connection between AP severity and the Triglyceride glucose (TYG) index.Methods: This research included 60 individuals who met the clinical criteria for AP and was an observational prospective cohort. Two categories of patients were identified: the severe group (n = 17) and the non-severe group (n = 43). For each patient, the TYG index was computed as follows: ln [fasting plasma glucose (mg (dL) × fasting TG (mg/dL)]2.Results: TYG index was significantly higher in severe group. TYG index can significantly predict severity of AP (P=0.002 and AUC = 0.741) at cut-off >5.16 with 76.47% sensitivity, 72.09% specificity, 68.9% PPV and 78.2% NPV.Conclusions: The results of this research indicate that the TYG index exhibits independent prognostic value in individuals diagnosed with AP. Furthermore, we propose that the TYG index serve as a prognostic tool for SAP when a cut-off value of >5.16 is used. The sensitivity of this cut-off value is determined to be 76.47%, while the specificity is 72.09%. Additionally, the positive predictive value (PPV) is calculated to be 68.9%, and the negative predictive value (NPV) is determined to be 78.2%. There is a direct link between the frequency of SAP and AP-related problems and a high TYG index.