The effect of phosphatidylserine supplementation on athletic performance: A systematic review of randomized clinical trials

Abstract

This review aims to critically evaluate the existing evidence derived from randomized clinical trials to determine the effectiveness of phosphatidylserine in enhancing athletic performance. Extensive searches were conducted in databases including PubMed, ClinicalTrials.gov, Google Scholar, Embase, Web of Science, CINAHL, and Medline. Among the initially identified 538 articles with potential relevance, a thorough assessment of full-text articles was performed, resulting in the inclusion of seven studies that satisfied all predefined inclusion criteria. All studies were evaluated as having a low risk of bias. Five of the included studies reported statistically significant differences before and after intervention, thus providing support for the use of phosphatidylserine as a supplement to support athletic performance. However, despite these promising results obtained from clinical trials, the current evidence remains insufficient to firmly endorse the use of phosphatidylserine for its impact on athletic performance.