In silico and in vitro antimicrobial testing of ethanol extract of Xylopia aethiopica against Salmonella typhimurium and Shigella species isolated from Wistar rats infected with Trypanosoma evansi and Trypanosoma brucei brucei

Abstract

Plants with antimicrobial potential have been implicated in the treatment of infections. Studies have shown that extracts from diverse plants have shown antibacterial and or antitrypanosomal activities against infectious agents. This research examined the in vitro antimicrobial testing of ethanol extract of Xylopia aethiopica against Salmonella typhimurium and Shigella species isolated from wistar mouse already infected with Trypanosoma evansi and Trypanosoma brucei brucei. Sixty (60) wistar mouse of 16 weeks old were used and were randomly grouped into 8 groups where N = 5 in group A, B, E, F,G and H. N=15, in C and D. group A: control, group B uninfected but treated (346.4 mg/kg/bwt XAEE. Group C infected untreated (T. Brucei brucei), Group D infected untreated (T. evansi). Group E infected treated (T. Brucei brucei 346.4 mg/kg/bwt XAEE). Group F. infected treated (T. evansi 346.4 mg/kg/bwt XAEE). When molecular docking simulation was used, lots of phytochemicals were identified and screened in the XAEE used in this study. Findings from this study have shown an indication of in vitro antimicrobial activities of ethanol extract of Xylopia aethiopica fruits against Salmonella typhimurium and Shigella species examined.