Study of 3-(1-hydroxy naphthalene-2-yl)-5-(furan-2-yl)-1-substituted pyrazolines

Abstract

2-acetyl-1-naphthol 2 is prepared by Modified Nenchis method which on treatment with furfuraldehyde and KOH gives 1-(1-hydroxy naphthalen-2-yl)-3-(furan-2-yl) prop-2-ene-1-ones 3 in excellent yield. The chalcone 3 when subjected to hydrazine / phenyl hydrazine/ semicarbazide / 2,4 dinitro phenyl hydrazine / isonicotinic acid hydrazide in DMF solvent gives 3-(1-hydroxy naphthalene-2-yl)-5-(furan-2-yl)-1-substituted pyrazolines 4, 5, 6, 7 and 8 in 35-45% yield. The structural assignments to the compounds 4, 5, 6, 7 and 8 are based on their elemental analysis and spectral data.