Evaluation of Pteleopsis suberosa Smith and Nauclea latifolia Engl and Diels effects on cholesterolemic overload in rats

Abstract

Nauclea latifolia (N. latifolia) and Pteleopsis suberosa (P. suberosa) are two medicinal plants used to treat several pathologies linked to oxidative stress. This study aims to study the effects of ethanolic extracts from those two plants on the consequences of cholesterolemic overload. Oxidative stress was induced by cholesterolemic overload. In vitro antioxidant activity was evaluated using DPPH, total phenolic compounds and flavonoids assays; while in vivo FRAP test and determination of malondihaldehyde (MDA) content in the liver and the kidney tissus were assayed. Lipid profile was studied by assaying triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol. Blood glucose, ALAT and ASAT content were determined. P. suberosa showed higher antioxidant activity in vitro and higher level of phenolic compounds and flavonoids as compared to N. latifolia. FRAP test showed that N. latifolia significantly increased Fe2+ content. Organs MDA content was significantly reduced by P. suberosa at 200 mg/kg. Both extracts reduced LDL-cholesterol levels and increased HDL-cholesterol significantly. Results also suggest that, N. latifolia and P. suberosa may contribute to the prevention and treatment of oxidative stress and hypercholesterolemia related diseases.