Hypoglycemic and renoprotective effect of Cichorium intybus var, Moringa oleifera and Olea europaea.

Abstract

Diabetes mellitus has a prevalence of 14% in the Mexican Republic, and the population continues to use medicinal plants in their treatment, of which their therapeutic properties must be corroborated. Objective: To study the hypoglycemic and nephroprotective properties of fresh leaves of Olea europaea, Moringa oleifera, and Cichorium intybus var. in a model of diabetes mellitus in rats. Methods: Diabetes mellitus was induced in rats by treatment with streptozotocin (55 mg/kg), intraperitoneally. From the fourth day, ethanolic extracts from fresh leaves of plants (100 and 200 mg/kg, orally) were given to diabetic rats for 2 weeks. Flavonoids, phenolic acids, and terpenoids were determined by HPLC in extracts. Blood glucose, proteinuria and renal hypertrophy were evaluated. Extracts of O. europaea, M. oleifera, and C. intybus var showed hypoglycaemic and renoprotective effects in diabetic rats.