Formulation and evaluation of curcumin emulgel for topical delivery

Abstract

Topical drug delivery system is the application of the formulation onto the skin directly treat skin diseases. The gel formulation has a disadvantage to delivery hydrophobic drugs. This can be overcome by formulating novel drug delivery known as Emulgel. Emulgel combines two formulation gel and emulsion. The Emulgel is used to treat skin infections like fungal infections, acne, and psoriasis. The emulgel was formulated and characterised for FTIR studies, pH analysis, spredability, swelling index, drug content, globules size, in-vitro drug release, comparative in-vitro drug release studies, SEM studies and in-vitro drug release kinetics using zero order, first order, highchair model and korsmeyer papas model. FTIR studies provided no evidence of chemical interaction between curcumene and excipients used. The pH of the formulations was within an appropriate range for skin. The swelling index and spredability were optimum for the better patient compliance.