In-vivo assessment of the antiplasmodial efficacy of corchorus catharticus Blanco whole plant extract

Abstract

Malaria is a disease of global concern, with a greater threat impact in Sub-Saharan Africa. With the emergence of multidrug-resistant strains of Plasmodium species, and the dissemination of resistance within disease vectors to vector control modalities; with a lack of vaccine. The need, therefore, exists for the search and screening of newer and better molecules of promising efficacy in the treatment of malaria. The aim of this study was to assess the in vivo antiplasmodial efficacy of Corchorus catharticus Blanco whole plant extract, an efficacy of 20% and 47% was recorded for suppressive and curative tests respectively at the highest dose of 600mg/kg/b.w. the positive control (Arthemeter / Lumenfantrine) had an efficacy of 80% and 94% for suppressive and curative tests respectively. This study suggests and supports the use of Corchorus catharticus Blanco in ethno medicine for malaria treatment, due to its promising antiplasmodial efficacy.