Serum glutamate pyruvate transaminase (SGPT) levels and histopathological of KUB chicken liver given water extract of neem leaves (Azadirachta indica) in drinking water

Abstract

Azadirachta indica A. Juss or neem is herbal that contains antioxidants and bioactive compounds of alkaloids, steroids, flavonoids, saponins and tannins that can play a role in various biological activities. The purpose of this study was to determine the effect of water extract of neem leaves mixed in drinking water on the liver health performance of KUB chickens. The observed variables were serum glutamate pyruvate transaminase (SGPT) levels and liver histopathology. The experimental animals used were KUB chickens (Kampung Unggul Balitbangtan), using a Completely Randomized Design (CRD) with four treatments and five replications. The treatment group consisted of P0 (control or 0%), neem leaf water extract 1% (P1), 3% (P2) and 5% (P3) administered during the starter phase (42 days). The experimental animals used were 200 tails. Preparation of liver histology preparations by paraffin method. SGPT levels were tested by the IFCC2 Enzymatic Kinetic method (International Federation of Clinical Chemistry and Laboratory Medicine). The results showed that KUB chicken SGPT levels were not significantly different between control and treatment. Liver histology data showed inflammatory cell infiltration damage, degeneration, necrosis, and vessel congestion but there was no significant difference between control and treatment chicken livers. Water extract supplementation of neem leaf has no negative effect on liver performance and SGPT levels