Plasma cell dyscrasias with complete loss of immunoglobulin heavy chain expression: A rare case

Abstract

Background: We are presenting a cases of the monoclonal plasma cell proliferative disorders with complete loss of immunoglobulin heavy chain (HC) expression, which is not LC-MGUS. Method: Many literatures and text books were being reviewd regarding the classification, presentation and annual progression rate of Light chain myeloma and other dyscrasias expressing only light chain.Result: Literature data is very scarce. Most of the literatures are batting around LC-MGUS, but not beyond that. Conclusions: More light should be thrown on this darker area of light chain expressing plasma cell dyscrasias for better management.