articleTop 1% cited
Enantioselective Mannich‐Type Reaction Catalyzed by a Chiral Brønsted Acid
Angewandte Chemie · 2004 · Vol. 116(12) · pp. 1592–1594
Takahiko Akiyama✉(Gakushuin University)Junji Itoh(Gakushuin University)Koji Yokota(Gakushuin University)Kohei Fuchibe(Gakushuin University)
Abstract
Ganz ohne Metall: Die Mannich-Reaktion der Ketensilylacetale 2 mit Aldiminen 1 liefert unter dem Einfluss einer chiralen, von (R)-BINOL abgeleiteten Brønsted-Säure (4) mit bis zu 96 % ee die syn-Isomere 3 von β-Aminoestern.
Axial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralitySurface Chemistry and CatalysisEnantioselective synthesisChemistryBrønsted–Lowry acid–base theoryMannich reactionCatalysisStereochemistryOrganic chemistryMedicinal chemistry
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