Histopathological spectrum of diseases in gall bladder

Abstract

Context: The histopathological spectrum of diseases in gall bladder ranges from inflammation to benign to malignant lesions. The present study was undertaken to emphasize on the need of histomorphological analysis of all gall bladder specimens, for the diverse findings that may be identified. Methods: A cross-sectional observational study was undertaken at a tertiary care teaching hospital in Central Gujarat, India where clinical, radiological and pathological findings of 360 cholecystectomies specimen were studied between April 2016 to May 2021 (5 years). Results: A female preponderance (M:F ratio =2:3) with a predilection for the fifth and sixth decade of life was noted in the total 360 specimens studied. Histomorphological spectrum included cholelithiasis [222 cases (61.1%)] followed by cholecystitis [107 cases (29.7%)] and neoplasms [24 cases (6.6%)] Conclusion: The present study supports the dictum that histopathological analysis of all cholecystectomy specimens should be done, as it may reveal a wide spectrum of abnormalities, undiagnosed by clinical and imaging studies.