article Open AccessTop 1% cited
Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury
Critical Care · 2021 · Vol. 25(1) · pp. 356–356
Yang Jiao✉(XinHua Hospital)Ti Zhang(Nanjing General Hospital of Nanjing Military Command)Chengmi Zhang(XinHua Hospital)Haiying Ji(XinHua Hospital)Xingyu Tong(XinHua Hospital)Xia Ran(XinHua Hospital)Wei Wang(XinHua Hospital)Zhengliang Ma(Nanjing Drum Tower Hospital)Xueyin Shi(XinHua Hospital)
Abstract
The present study demonstrated that exosomal miR-30d-5p from PMNs contributed to sepsis-related ALI by inducing M1 macrophage polarization and priming macrophage pyroptosis through activating NF-κB signaling. These findings suggest a novel mechanism of PMN-Mϕ interaction in sepsis-related ALI, which may provide new therapeutic strategies in sepsis patients.
Inflammasome and immune disordersInflammation biomarkers and pathwaysImmune cells in cancerPyroptosisMedicineMacrophage polarizationSepsisMacrophageImmunologyLungInflammationInternal medicineInflammasome
MeSH terms
PyroptosisAnimalsHumansMacrophage ActivationMacrophagesMice, Inbred C57BLNeutrophilsTumor Necrosis Factor-alphaNF-kappa BSepsisMicroRNAsMiceAcute Lung Injury
Funding
- National Natural Science Foundation of China
Citations
541
FWCI
29.62
field-weighted impact
References
42
Percentile
100%
vs. same field & year
Citations per year
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