Comparative study of significance of serum matrix metalloproteinase-13 (MMP-13) and carbohydrate antigen 15.3 (CA15.3) as an early tumor marker in female patients with breast cancer

Abstract

Aim: To determine the usefulness of serum Matrix metalloproteinase-13 (MMP-13) along with Carbohydrate Antigen 15.3 (CA15.3) as an early tumor marker in female patients with breast cancer.Method: The breast cancer patients were recruited from OPD/IPD of Surgery and Oncology department of SMS Hospital, and evaluated serum MMP-13 and CA15.3. Total 180 subjects were included in this study.90 breast cancer Patients were divided according to different stages and 90 control subjects also included.Results: Serum MMP-13 and CA15.3 level raised significantly in breast cancer patients. Further increases with the advanced stage of the breast cancer.Conclusion: Both MMP-13 and CA15.3 can be useful diagnostic tumor marker in breast cancer.