Traditional uses, phytochemistry and pharmacology of Commelina diffusa Burm: An updated systematic review

Abstract

The goal of this research is to compile information on Commelina diffusa's traditional applications, phytochemistry, and pharmacological activity. Scientific databases such as PubMed, Google, Google Scholar, and Research gate were searched using certain keywords. It's been used for centuries to treat urinary tract infections, swellings, inflammation, diarrhoea, hemorrhoids, conjunctivitis, and ophthalmia. Alkaloids, flavonoids, saponins, tannins, cardiac glycosides, terpenoids, and steroids were discovered by phytochemical analysis. The existence of 21 phytochemical components was confirmed by GC-MS spectrum profiles, the majority of which were sterols, terpenoids, and alkanes. Commelina diffusa contains anti-inflammatory, antioxidant, antibacterial, and antifungal, nephro-protective, hepatoprotective, diuretic and CNS depressant properties, according to scientific evidence. Toxicologically, there was no evidence of toxicity. More research is needed to determine the processes that mediate the plant's bioactivities in connection to therapeutic purposes, as well as to look into any potential toxicity in preparation for future clinical trials.