Effect of different extracts of R. emodi on hemato-biochemical parameters in rabbit wound healing model

Abstract

The present study was aimed to evaluate the toxicity effect of different extracts of R. emodi, used for treatment of excisional full-thickness skin wounds.Method: Thirty clinically healthy rabbits were divided into 4 equal groups. Two excisional wounds (1.5×1.5 cm) on the dorsal spine were created in all under general anesthesia. Except for the first group treated with povidone iodine which served as control, all the other groups were treated R. emodi extracts (ethanolic extract, aqueous extract and petroleum-ether extract). Evaluation of its effects on different hematological and biochemical parameters were recorded at different intervals of the study.Results: The haematological indices and biochemical indices of rabbits in treatment group returned to normal level much earlier than the control group. In the petroleum ether treated group the increase in protein values was found earlier. Also the glucose values were low in all treated group with lowest being in ethanolic extract treated group.Conclusion: No hepato toxicity and nephro toxicity was reported in R. emodi extract treated groups. 10% ethanolic, aqueous and P. ether extract ointments of R. emodi are safe to use in full-thickness wounds in rabbits.