Biochemical evaluation of ulcer curative effect of ethanolic and aqueous extracts of Schwenkia americana Linn on experimental rats

Abstract

Gastric ulcers are common and serious diseases in the world. The study assessed the effect of the ethanolic and aqueous extract of Schwenkia americana Linn on aspirin-induced gastric ulcers in Wistar rats. 200 mg/kg body weight of aspirin was used to produce ulcers in rats for 3 days. After checking for the presence of ulcers, the ulcerogenic rats were divided in 4 groups of 6 rats. 2 groups were treated with ethanolic or aqueous extract, while a group received Omeprazole in 28 days and the last group was the ulcer untreated control. There were significant increases in free and total acidity, serum alkaline phosphatase and ulcer score in aspirin treated group compared to the control group. Aspirin induced distinct gastric histological changes compared with the control group, while the plant extracts ameliorated these changes which showed that the plant extracts has a regenerative potentials as an antiulcer agent.