Conception of trapping cidal spray constituents using blend masks in agricultural practices within western region of India

Abstract

For farmers, pesticides and insecticides are both allies and enemies. The long-term risks they generate can have significant adverse effects on farmers. In order to avoid pests and insects, the application of these chemicals in the field is also important. In the recent years, serious attention has been paid to the harmful effects of pesticides on the environment and human health by the public authorities. It is necessary for farmers to wear protective equipment in this condition to avoid the inhalation as well as absorption of these chemicals (by skin). These chemicals cause have side effects ranging from nausea, headache, temporary blindness to adverse health conditions like permanent blindness, respiratory disorder, nervous system problem, and cancer. A survey was conducted in the western region of India where 30 chemicals were auditioned among which malathione, pyrethroids and cyhalothrin got selected for further progress. Upon docking these chemicals with neutrophil elastase, cholestrerly ester transfer, G alpha, β-arrestin proteins. We found that these chemicals showed affinity with a high binding interaction towards the aromatic amino acids residues that can form H- bonds with a higher binding interaction. Therefore, from our in-silico findings we hypothesize that peptide matrix will be a good candidate for preparing blended masks to entrap the hazardous chemicals from the sprays.