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Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study
BMJ · 2021 · Vol. 373 · pp. n1088–n1088
Jamie Lopez Bernal✉(Public Health England)Nick Andrews(Public Health England)Charlotte Gower(Public Health England)Chris Robertson(University of Strathclyde)Julia Stowe(Public Health England)Elise Tessier(Public Health England)Ruth Simmons(Public Health England)Simon Cottrell(Public Health Wales)Richard J. Roberts(Public Health Wales)Mark G. O’Doherty(Public Health Agency)Kevin Brown(Public Health England)Claire Cameron(Health Protection Scotland)Diane Stockton(Health Protection Scotland)Jim McMenamin(Health Protection Scotland)Mary Ramsay(Public Health England)
Abstract
Vaccination with either one dose of BNT162b2 or ChAdOx1-S was associated with a significant reduction in symptomatic covid-19 in older adults, and with further protection against severe disease. Both vaccines showed similar effects. Protection was maintained for the duration of follow-up (>6 weeks). A second dose of BNT162b2 was associated with further protection against symptomatic disease. A clear effect of the vaccines against the B.1.1.7 variant was found.
SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 epidemiological studiesCoronavirus disease 2019 (COVID-19)Medicine2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PediatricsTest (biology)Family medicineVirologyInternal medicineOutbreak
MeSH terms
COVID-19SARS-CoV-2COVID-19 VaccinesCOVID-19 TestingBNT162 VaccineChAdOx1 nCoV-19AgedAged, 80 and overEnglandFemaleHospitalizationHumansMaleVaccinationCase-Control Studies
Funding
- Public Health England
Citations
1,387
FWCI
85.37
field-weighted impact
References
26
Percentile
100%
vs. same field & year
Citations per year
References
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
New England Journal of Medicine · 2020 · 15,281 citations
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