article Open AccessTop 1% cited
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
The Lancet · 2020 · Vol. 397(10269) · pp. 99–111
Merryn Voysey✉(University of Oxford)Sue Ann Costa Clemens(University of Siena)Shabir A. Madhi(South African Medical Research Council)Lily Yin Weckx(Universidade Federal de São Paulo)Pedro M. Folegatti(University of Oxford)Parvinder K. Aley(University of Oxford)Brian Angus(University of Oxford)Vicky L. Baillie(University of the Witwatersrand)Shaun Barnabas(Stellenbosch University)Qasim Bhorat(Soweto CTC)Sagida Bibi(University of Oxford)Carmen Briner(University of the Witwatersrand)Paola Cicconi(University of Oxford)Andrea M. Collins(Liverpool School of Tropical Medicine)Rachel Colin-Jones(University of Oxford)Clare Cutland(University of the Witwatersrand)Thomas C. Darton(Sheffield Teaching Hospitals NHS Foundation Trust)Keertan Dheda(University of London)C.J. Duncan(Newcastle upon Tyne Hospitals NHS Foundation Trust)Katherine R. W. Emary(University of Oxford)Katie Ewer(University of Oxford)Lee Fairlie(University of the Witwatersrand)Saul N. Faust(University Hospital Southampton NHS Foundation Trust)Shuo Feng(University of Oxford)Daniela M. Ferreira(Liverpool School of Tropical Medicine)Adam Finn(University Hospitals Bristol NHS Foundation Trust)Anna L. Goodman(St Thomas' Hospital)Catherine Green(University Hospitals Birmingham NHS Foundation Trust)Christopher Green(University Hospitals Birmingham NHS Foundation Trust)Paul T. Heath(St George's, University of London)Catherine Hill(University of the Witwatersrand)Helen Hill(Liverpool School of Tropical Medicine)Ian Hirsch(AstraZeneca (United Kingdom))Susanne H. Hodgson(University of Oxford)Alane Izu(Right to Care)Susan Jackson(University of Oxford)Daniel Jenkin(University of Oxford)Carina C. D. Joe(University of Oxford)Simon Kerridge(University of Oxford)Anthonet Koen(Right to Care)Gaurav Kwatra(University of the Witwatersrand)Rajeka Lazarus(North Bristol NHS Trust)Alison M. Lawrie(University of Oxford)Alice Lelliott(University of Oxford)Vincenzo Libri(UCL Biomedical Research Centre)Patrick Lillie(University of Hull)Raburn M. Mallory(AstraZeneca (United Kingdom))Ana Verena Almeida Mendes(Escola Bahiana de Medicina e Saúde Pública)Eveline Pı́polo Milan(Universidade Federal do Rio Grande do Norte)Angela M. Minassian(University of Oxford)Alastair McGregor(London North West Healthcare NHS Trust)Hazel Morrison(University of Oxford)Yama F Mujadidi(University of Oxford)Anusha Nana(University of the Witwatersrand)Peter O’Reilly(University of Oxford)Sherman D. Padayachee(Setshaba Research Centre)Ana Maria Pittella(Universidade Unigranrio)Emma Plested(University of Oxford)Katrina M. Pollock(NIHR Imperial Biomedical Research Centre)Maheshi Ramasamy(University of Oxford)Sarah Rhead(University of Oxford)Alexandre Vargas Schwarzbold(Universidade Federal de Santa Maria)Nisha Singh(University of Oxford)Darren Smith(University of Glasgow)Rinn Song(Boston Children's Hospital)Matthew D. Snape(University of Oxford)Eduardo Sprinz(Universidade Federal do Rio Grande do Sul)Rebecca Sutherland(Western General Hospital)Richard Tarrant(University of Oxford)Emma C. Thomson(MRC University of Glasgow Centre for Virus Research)M. Estée Török(University of Cambridge)Mark Toshner(Papworth Hospital NHS Foundation Trust)David P. J. Turner(Nottingham University Hospitals NHS Trust)Johan Vekemans(AstraZeneca (United Kingdom))Tonya Villafana(AstraZeneca (United Kingdom))Marion Watson(University of Oxford)Christopher J. Williams(Aneurin Bevan University Health Board)Alexander D. Douglas(University of Oxford)Adrian V. S. Hill(University of Oxford)Teresa Lambe(University of Oxford)Sarah C. Gilbert(University of Oxford)Andrew J. Pollard(University of Oxford)Marites AbanFatola AbayomiKushala W.M. AbeyskeraJeremy AboagyeMatthew AdamKirsty AdamsJames P. AdamsonYemi AdelajaGbadebo AdewetanSyed AdlouKhatija AhmedYasmeen AkhalwayaSaajida AkhalwayaAndrew Alcock(University of London)Aabidah Ali(University of London)Elizabeth AllenLauren AllenThamires C. D. S. C AlmeidaMariana AlvesFábio Ferreira AmorimFoteini AndritsouRachel AnslowMatthew ApplebyEdward H. Arbe-BarnesMark P. AriaansBeatriz ArnsLaiana ArrudaPaula De Almeida AziLorena AziGavin BabbageCatherine BaileyKenneth F. BakerMegan BakerNatalie BakerPhilip BakerLisa BaldwinIoana BaleanuDanieli BandeiraAnna BaraMarcella A.S. BarbosaDebbie BarkerGavin BarlowEleanor BarnesAndrew BarrJordan R. BarrettJessica BarrettLouise BatesAlexander BattenKirsten BeadonEmily BealesRebecca BeckleySandra Belij‐RammerstorferJonathan BellDuncan Bellamy(University of London)Nancy BelleiSue BeltonAdam BergLaura M. BermejoEleanor BerrieLisa BerryDaniella BerzenyiAmy BeveridgeKevin R. BewleyHelen BexhellSutika BhikhaAs’ad E. BhoratZaheda E. BhoratElse M. BijkerGeeta BirchSarah BirchAdam BirdOlivia BirdKaren BisnauthsingMustapha BittayeK. Blackstone(University of London)Luke BlackwellHeather BletchlyCaitlin L. BlundellSusannah R. BlundellPritesh BodaliaBruno Cruz BoettgerEmma BolamElena BolandDaan BormansNicola BorthwickFrancesca BowringAmy BoydPenny BradleyTanja BrennerPhillip J. BrownClaire BrownCharlie Brown-O’SullivanS BruceEmily BruntRuaridh BuchanWilliam BuddYusuf A. BulbuliaMelanie BullJamie BurbageHassan BurhanAileen BurnKaren R. ButtigiegNicholas ByardIngrid Cabera PuigGloria CalderónAnna CalvertSusana CamaraMichelangelo CaoFederica CappucciniJoão C. R. CardosoMelanie CarrMiles W. CarrollAndrew Carson‐Stevens(University of London)Yasmin de M. CarvalhoJosé Antônio Mainardi de CarvalhoHelen R. CaseyPaul Cashen(University of London)Thaís Castro RibeiroLucía Carratalá-CastroKatrina CathieAna CaveyJosé Cerbino-NetoJim ChadwickDavid ChapmanSue CharltonIrina ChelyshevaOliver ChesterSunder ChitaJee-Sun ChoLiliana CifuentesElizabeth ClarkMatthew ClarkAndrea ClarkeElizabeth ClutterbuckSarah L.K. CollinsChristopher P. ConlonSean ConnartyNaomi S. CoombesCushla CooperRachel CooperLynne CornelissenTumena CorrahCatherine CosgroveTony CoxWendy E.M. CrockerSarah CrosbieLorraine CullenDan CullenDebora R.M.F. CunhaChristina J. CunninghamFiona C. CuthbertsonSuzete Nascimento Farias da GuardaLarissa P. da SilvaBrad E. DamratoskiZsofia DanosMaria T.D.C. DantasPaula DarrochMehreen S. DatooChandrabali DattaMalika DavidsSarah L. DaviesH. Dele DaviesElizabeth J. DavisJudith A. DavisJohn D. DavisMaristela Miyamoto de NobregaLis Moreno De Oliveira KalidDavid DearloveTesfaye DemissieAmisha DesaiStefania Di MarcoClaudio Di MasoMaria Isabel Saraiva DinelliTanya DineshClaire DockseyChristina DoldTao DongFrancesca R. DonnellanTannyth Dos SantosThainá G. dos SantosErika Pachecho Dos SantosNaomi Douglas(University of London)Charlotte DowningJonathan DrakeRachael Drake-BrockmanKimberley DriverRuth DrurySusanna DunachieBenjamin DurhamLidiana DutraNicholas EasomSamual van EckMandy EdwardsNick J. EdwardsOmar M. El MuhannaSean C. EliasMike ElmoreMarcus Rex EnglishAlisgair EsmailYakub Moosa EssackEoghan C. W. FarmerMutjaba FarooqMadi FarrarLeonard FarrugiaBeverley FaulknerSofiya FedosyukSally FelleShuo Feng(University of Oxford)Carla Ferreira Da SilvaSamantha FieldRichard FisherAmy FlaxmanJames L. K. FletcherHazel FofieHenry FokKaren FordJamie FowlerPedro Henrique Almeida FraimanEmma FrancisMarília Miranda FrancoJohn FraterM FreireSamantha H. FrySabrina FudgeJulie FurzeMichelle FuskovaPablo Galian-RubioEva GalizaHarriet GarlantMadita GavrilaA GeddesKaryna A. GibbonsCiarán GilbrideHardeep Singh GillSharon A. GlynnKerry GodwinKarishma GokaniUrsula Carvalho GoldoniMaria GoncalvesIsabela G. S. GonzalezJayne GoodwinAmina GoondiwalaKatherine Gordon-Quayle(University of London)Giacomo GoriniJanet GrabLara GracieMelanie GreenlandNicola M. GreenwoodJohann GreffrathMarisa GroenewaldLeonardo GrossiGaurav GuptaMark J. HackettBassam HallisMainga HamalubaElizabeth HamiltonJoseph HamlynDaniel HammersleyAidan T. HanrathBrama HanumunthaduStephanie A. HarrisClair HarrisTara HarrisT. D. HarrisonDaisy HarrisonThomas C. HartBirgit HartnellShadin HassanJohn HaughneySophia HawkinsJodie HayIan M. HeadJohn A. HenryMacarena Hermosin HerreraDavid HettleJennifer HillGina HodgesElizea HorneMimi M. HouCatherine HoulihanElizabeth HoweNicola HowellJonathan HumphreysHolly E. HumphriesKatrina HurleyClaire HusonAngela Hyder-WrightCatherine HyamsSabina IkramAlka IshwarbhaiMonica IvanPoppy IvesonVidyashankara IyerFrederic JacksonJeanne De JagerShameem Z. JaumdallyHelen JeffersNatasha JesudasonBryony A. Jones(UCL Biomedical Research Centre)Kathryn Jones(UCL Biomedical Research Centre)Elizabeth Jones(UCL Biomedical Research Centre)Christopher Jones(UCL Biomedical Research Centre)Marianna Rocha JorgeAylin JoseAmar JoshiEduardo A.M.S. JúniorJoanne KadziolaReshma KailathFaeeza KanaKonstantinos KarampatsasMwila KasanyingaJade KeenElizabeth J. KellyDearbhla KellyDebbie M. KellySarah KellyDavid KerrRenato de Ávila KfouriLiaquat KhanBaktash KhozoeeSarah KiddAnnabel KillenJasmin KinchPatrick KinchLloyd D. W. KingThomas KingLucy KinghamPaul Klenerman(University of London)Francesca KnapperJulian C. KnightDaniel KnottStanislava KolevaMatilda LangGail LangColin W. LarkworthyJessica P. J. LarwoodRebecca‐Jane Law(University of London)Erica LazarusAmanda LeachEmily A. LeesNana‐Marie LemmAlvaro Edson Ramos LessaStephanie LeungYuanyuan Li(University of London)Amelia M. LiasKonstantinos LiatsikosAline LinderSamuel LipworthShuchang LiuXinxue LiuAdam LloydStephanie LloydLisa LoewRaquel Lopez RamonLeandro Bonecker LoraVicki LowthorpeKléber Giovanni LuzJonathan MacdonaldGordon MacGregorMeera MadhavanDavid O. MainwaringEdson MakambwaRebecca MakinsonMookho MalahlehaRoss MalamatshoGarry MallettKushal MansattaTakalani MaokoKatlego MapetlaNatalie G. MarchevskySpyridoula MarinouEmma MarlowGabriela N. MarquesPaula MarriottRichard P. MarshallJulia L. MarshallFlávia J. MartinsMasebole MasenyaMduduzi MasilelaShauna K. MastersMoncy MathewHosea MatlebjaneKedidimetse MatshidisoOlga MazurAndrea MazzellaHugh McCaughanJoanne McEwanJoanna McGlashanLorna McInroyZoe McIntyreDaniela McLenaghanNicky McRobertSteve McSwigganClare MegsonSavviz MehdipourWilma MeijsRenata MendonçaAlexander J. MentzerNeginsadat MirtorabiCelia MittonSibusiso MnyakeniFiona MoghaddasKgaogelo MolapoMapule MoloiMaria MooreM. Isabel Moraes-PintoMarni MoranElla MoreyRóisín MorgansSusan MorrisSheila MorrisHelen MorrisFranca MorselliGertraud MorsheadRichard MorterLynelle MottalAndrew Moultrie(University of London)Nathifa MoyaMushiya MpelembueSibekezelo MsomiYvonne MugodiEkta MukhopadhyayJilly MullerAlasdair MunroClaire MunroSarah MurphyPhilomena MweuCelia Hatsuko MyasakiGurudutt NaikKush NakerEleni NastouliAbida NazirBongani NdlovuF NeffaCecilia NjengaHelena Carolina NoalAndrés NoéGabrielle Gonçalves de NovaesFay L. NugentGéssika Lanzillo A. NunesKatie M. O’Brien(UCL Biomedical Research Centre)Daniel O’ConnorMiranda OdamSuzette OelofseBlanché OgutiVictoria OlchawskiNeil J. OldfieldMarianne Garcia de OliveiraCatarina OliveiraA OosthuizenPaula O'Reilly(University of Oxford)Piper OsborneDavid R. OwenLydia OwenDR OwensNelly OwinoMihaela PacurarBrenda Lopes PaivaEdna M.F. PalharesSusan PalmerS. N. PARKINSONHelena ParrachoKaren ParsonsDipak PatelBhumika PatelFaeezah PatelKelly PatelMaia Patrick-SmithRuth PayneYanchun PengElizabeth J. PennAnna PenningtonMarco Polo Peralta ÁlvarezJames PerringNicola PerryRubeshan PerumalSahir Yusuf PetkarTricia PhilipDaniel J. PhillipsJennifer PhillipsMary Kgomotso PhohuLorinda PickupSonja PieterseJo Piper(University of London)Dimitra PipiniMary PlankJoan Du PlessisS. Pollard(University of London)Jennifer PooleyAnil PooranIan PoultonClaire PowersFernando B. PresaDavid PriceVivien PriceMarcelo Ribeiro PrimeiraPamela C. ProudSamuel Provstgaard-MorysSophie PueschelDavid PulidoSheena QuaidRia RabaraAlexandra RadfordKajal RadiaDurga RajapaskaThurkka RajeswaranAlberto San Francisco RamosFernando Ramos LopezTommy RamplingJade RandHelen RatcliffeTom RawlinsonDavid ReaByron ReesJesús ReinéMila Resuello-DautiEmilia Reyes PabonCarla M. RibieroMarivic RicamaraAlex RichterNeil RitchieAdam RitchieAlexander J. RobbinsHannah RobertsRyan RobinsonHannah RobinsonTalita Trevizani RocchettiBeatriz Pinho RochaSophie RocheChristine S. RollierLouisa RoseAmy RussellLindie RossouwSimon RoyalIndra RudiansyahSarah RuizStephen SaichClaudia SalaJessica SaleAhmed M. SalmanNatalia SalvadorStephannie SalvadorMilla Dias SampaioAnnette D. SamsonAmada Sanchez-GonzalezHelen SandersKatherine Sanders(University of London)Erika SantosMayara F.S. Santos GuerraIman SattiJack E. SaundersCaroline SaundersAakifah Bibi Arif SayedIna Schim van der LoeffAnnina B. SchmidElla SchofieldGavin ScreatonSamiullah SeddiqiRameswara R. SegireddyRoberta SengerSonia SerranoRajiv ShahImam H. ShaikHannah SharpeKatherine Sharrocks(University of London)R. H. ShawAdam SheaAmy ShepherdJames G. ShepherdFarah ShihamEmad SidhomSarah E. SilkAntonio Carlos da Silva MoraesGilberto Silva‐JuniorLaura Silva-ReyesAnderson Donelli da SilveiraMariana B.V. SilveiraJ. SinhaDonal SkellyDaniel C. SmithN SmithH. SMITHDavid J. SmithCatherine C. SmithAiranuedida Silva SoaresTiago SoaresCarla SolórzanoGuilherme Geraldo Lovato SorioKim SorleyTiffany Sosa-RodriguezCinthia M.C.D.L. SouzaBruno Solano de Freitas SouzaAlessandra R. SouzaAlexandra J. SpencerFernanda SpinaLouise SpoorsLizzie StaffordImogen StamfordIgor StarinskijRicardo SteinJill StevenLisa StockdaleLisa V. StockwellLouise StricklandArabella C. StuartAnn SturdyNatalina SuttonAnna SzigetiAbdessamad Tahiri‐AlaouiRachel TannerCarol TaoushanisAlexander W. TarrKeja TaylorUrsula TaylorIona J. TaylorJustin TaylorRebecca te Water NaudéYrene ThemistocleousAndreas C. ThemistocleousMerin ThomasKelly ThomasTonia M. ThomasAsha ThombrayilFawziyah ThompsonAmber ThompsonKevin ThompsonAmeeka ThompsonJulia ThomsonV Thornton-JonesPatrick J. TigheLygia Accioly TinocoGerlynn TiongsonBonolo TladinyaneMichele TomasicchioAdriana TomićSusan TonksJames TownerNguyen TranJulia A. TreeGerry TrillanaCharlotte TrinhamRose TrivettAdam TrubyBetty Lebogang TshekoAadil TurabiRichard TurnerCheryl TurnerMarta UlaszewskaBenjamin R. UnderwoodRachel VarugheseDennis VerbartMarije K. VerheulIason VichosTaiane Alves VieiraClaire S. WaddingtonLaura M. WalkerErica J. WallisMatthew E. WandDeborah WarbickT. M. WardellGeorge M. WarimweSarah WarrenBridget WatkinsEkaterina Watson(University of London)Stewart WebbAlice Webb-Bridges(University of London)Angela C WebsterJessica WelchJeanette WellsAlison C. WestCaroline WhiteRachel WhitePaul WilliamsRachel WilliamsRebecca WinslowMark WoodyerAndrew WorthDaniel WrightMarzena WroblewskaAndy YaoRafael Leal ZimmerDalila ZiziPeter Zuidewind
Abstract
UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca.
SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakInterimMedicineBetacoronavirusInterim analysisVirologyCoronavirus InfectionsSars virus
MeSH terms
COVID-19COVID-19 VaccinesChAdOx1 nCoV-19AdolescentAdultAgedBrazilDouble-Blind MethodFemaleUnited KingdomHumansMaleMiddle AgedSouth AfricaSingle-Blind Method
Funding
- Bill and Melinda Gates Foundation
- AstraZeneca
- Nottingham University Hospitals NHS Trust
- UK Research and Innovation
- Public Health Wales
- Coalition for Epidemic Preparedness Innovations
- Instituto D'Or de Pesquisa e Ensino
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Cambridge
- University of Oxford
- University of Nottingham
- University of Glasgow
- South African Medical Research Council
- Cambridge University Hospitals
- Universidade Federal do Rio Grande do Sul
- Universidade Federal de Santa Maria
- Fundação Lemann
- Medical Research Council
- Engineering and Physical Sciences Research Council
- NIHR Imperial Biomedical Research Centre
- NIHR Oxford Biomedical Research Centre
Citations
4,980
FWCI
111.76
field-weighted impact
References
14
Percentile
100%
vs. same field & year
Citations per year
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References
A Modified Poisson Regression Approach to Prospective Studies with Binary Data
American Journal of Epidemiology · 2004 · 9,254 citations
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