Comparative pharmacological evaluation in respect to non-polar and polar solvent extracts of the leaves of Syzygium balsameum & Syzygium formosum

Abstract

The present study was concerned with the evaluation of the medicinal value of the leaves of Syzygium balsameum & Syzygium formosum. The leaves of the S. balsameum and S. formosum were successively extracted with hexane, ethyl acetate, and methanol and designated as SBH, SBEa & SBM for S. balsameum and SFH, SFEa & SFM for S. formosum. Preliminary phytochemical screening of all the extracts revealed the presence of various phytochemical constituents. Evaluation of antioxidant capacity by DPPH method SBM showed more active than standard ascorbic acid. SFM also showed good scavenging activity compare to SBH, SBEa, SFH, SFEa. Total phenolic and flavonoids content of S. balsameum & S. formosum methanolic extracts exhibited more content compare to hexane & ethyl acetate extract. The total antioxidant capacity of all the extracts showed significant result. In case of cytotoxicity test all the extracts showed mild cytotoxic activity compare to STD. The S. balsameum showed more cytotoxic than S. formosum. The antimicrobial study of all the extracts showed moderate activity against different organisms but exhibit significant activity against Bacillus Cereus & Bacillus subtilis. All the extracts showed mild thrombolytic activity. The OGTT showed insignificant activity of hexane and ethyl acetate extracts compared to standard but methanol extract exhibited significant activity compared to control and standard. The results of castor oil and magnesium sulfate-induced diarrhea showed that, statistically insignificant reduction in the incidence and severity of diarrhea with a higher dose of all the extract. The finding of this study suggested that methanol extracts showed more pharmacological activity than others.