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Flow cytometric detection of CD79a expression in DMBA induced mammary tumour treated with withaferin a in female Sprague-Dawley rats

Journal of Entomology and Zoology Studies · 2021 · Vol. 9(1) · pp. 1002–1004

K. Pratheepa✉(Tamil Nadu Veterinary and Animal Sciences University)A. RajaR. SridharS. Ramesh(Tamil Nadu Veterinary and Animal Sciences University)

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Abstract

The present study was designed to examine the expression of CD79a, total B lymphocytes in DMBA (7,12-dimethylbenz[a]anthracene) induced rat mammary carcinogenesis by flow cytometry. Twenty four female Sprague-Dawley (SD) rats were equally distributed to control, DMBA, DMBA+Tamoxifen (Standard drug) and DMBA+Withaferin A groups. Peripheral blood was collected at the 120th day from the initial dose of DMBA and CD79a, total B lymphocytes were determined by using flow cytometry. There was a significant increase in the total B lymphocytes (CD79a) in the DMBA+Withaferin A group from the DMBA+Tamoxifen group indicating the immunostimulatory effect of Withaferin A.

Phytochemicals and Medicinal PlantsDMBAFlow cytometryWithaferin AInternal medicineBiologyCarcinogenesisEndocrinologyChemistryMedicineMolecular biology

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References

The Three Es of Cancer Immunoediting

Annual Review of Immunology · 2004 · 2,980 citations

Flow cytometric detection of CD79a expression in DMBA induced mammary tumour treated with withaferin a in female Sprague-Dawley rats

Journal of Entomology and Zoology Studies · 2021 · 1 citations

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