Synthesis and antibacterial screening of some novel cinnamic acid derivatives

Abstract

A series of cinnamic acid derivatives (TA1–TA12) were synthesized and tested for their in vitro antibacterial activity against different strains of bacteria. Ampicillin anitibiotic is taken as standard for antibacterial activity. This study found that out of 12 synthesized compounds 6 compounds namely TA1, TA4, TA5, TA7, TA8, TA11 showed good activity against different microorganism strains as compared to standard drug. Amongst the six compounds, it is further found that compounds TA5, TA8 and TA11 having 4-hydroxy group in their structure showed best antibacterial activity as compared to standard.