Piperine and its novel nano form target tumor necrosis factor-α (TNF-α) signaling in mouse model of lung tumor

Abstract

Preclinical studies suggest that diet rich in phytochemicals plays an important role in the prevention of the cancer. Piperine, in the dietary pepper, has been shown to exhibit various pharmacological actions. In this study, we investigated the mechanism by which piperine exhibits anti-inflammatory action against experimentally benzo(a)pyrene induced lung cancer. The expression of the tumor necrosis factor-α was up regulated in the benzo(a)pyrene group when compared to the piperine and its nanoform treated groups. We conclude that tumor necrosis factor-α enhances the tumour progression in the tumour group and piperine enhances anti-inflammatory action by down regulating the tumor necrosis factor-α expression in the mouse model.