In vitro antibacterial activity of biogenic gold nanoparticles from Murraya koenigii seed extract against pathogens associated with traumatic wound infections

Abstract

Nosocomial infection is a serious health hazard worldwide and bacteria associated wound infection has been regarded as the most common cause of this infection. Multidrug resistance bacterial pathogens infecting the nonsurgical traumatic wounds could be life threatening due to therapeutic limitations. The present study focuses on the synthesis and characterization of the gold nanoparticles from the seed extract of Murraya koenigii and its in vitro antibacterial efficacy against human pathogens Pseudomanas aeruginosa, Escherichia coli, Enterococcus spp and Staphylococcus aureus isolated from wounds. Results from Disc diffusion method indicate that the biogenic gold nanoparticles from Murraya koenigii seeds exhibited strong antibacterial activity against gram positive bacteria and moderate activity against gram negative bacteria.